Pycnogenol 50mg

Patented French Maritime Pine Bark Extract for Antioxidant Protection, Vascular Support & Women's Inflammatory Health

Pycnogenol® is one of the most extensively researched plant extracts, with over 40 years of clinical research and more than 160 published studies. Derived from the bark of French maritime pine trees grown along the southwest coast of France, it contains a unique combination of procyanidins, bioflavonoids, and organic acids that work together to neutralize free radicals, reduce inflammatory signaling, support the integrity of blood vessels and connective tissue, and protect cells from oxidative damage. Klaire Labs delivers it in its purest, most potent form: 50mg of standardized Pycnogenol® per capsule, with no unnecessary additives and no common allergens.

How Pycnogenol Works

Pycnogenol® is a natural nuclear factor-kappa B inhibitor, meaning it reduces chronic inflammation by blocking one of the central switches that drives inflammation. It also stimulates the production of nitric oxide to support vascular relaxation, inhibits platelet aggregation, and supports the body's own antioxidant enzymes including superoxide dismutase and glutathione peroxidase. Its proanthocyanidins bind selectively to collagen and elastin, protecting and supporting the structural integrity of blood vessels, capillaries, joints, and skin.

Pycnogenol® & Endometriosis

For women navigating endometriosis, Pycnogenol® has some of the most compelling evidence of any botanical. Endometriosis is fundamentally a condition of chronic inflammation, immune dysregulation, and estrogen-driven tissue proliferation, and Pycnogenol's NF-kB inhibiting and anti-inflammatory mechanisms address it at the root level.

A 2007 study of 58 women found Pycnogenol® alone to significantly reduce the symptoms of endometriosis by 33% without disruption to the menstrual cycle, allowing women to become pregnant. Notably, five women in the study left because they became pregnant during the trial.

A clinical study published in the International Journal of Women's Health found that oral contraceptives combined with Pycnogenol® resulted in significantly greater pain reduction than oral contraceptives alone. Most (56%) participants taking Pycnogenol® and an oral contraceptive reported a complete resolution of pain, while none of those taking an oral contraceptive alone reported full pain resolution.

The study was conducted in people with endometriomas and not only did Pycnogenol® lower pain, but it also lowered levels of CA125, a marker used clinically to monitor endometriosis and ovarian activity.

What Pycnogenol® Supports

• Endometriosis-related pelvic pain, menstrual cramping, and dysmenorrhea
• Chronic inflammatory conditions driven by NF-kB signaling
• Vascular integrity, capillary health, and healthy circulation
• Collagen and connective tissue support in joints, vessels, and skin
• Antioxidant protection and free radical neutralization
• Cardiovascular health and blood flow regulation
• Skin elasticity and healthy aging

Best For

Women navigating endometriosis, menstrual pain, or any condition with a chronic inflammatory component. Also an excellent daily antioxidant and vascular support formula for anyone prioritizing long-term cardiovascular and connective tissue health.

How to Use

Take 1 capsule 1 to 4 times daily with food, or as directed by your healthcare provider. For endometriosis support, clinical studies used doses ranging from 30 to 60mg daily. Consistent daily use over several months is where the benefit is most pronounced.

Consult your healthcare provider before use if you are pregnant, nursing, under 18, taking prescription medications, or managing a medical condition.

Clean Credentials

• Pycnogenol® is a registered trademark of Horphag Research with U.S. patent protection
• Free from all common allergens including milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soy, and sesame
• Non-GMO, vegan, no synthetic colors, flavors, or preservatives

Supplement Facts (per 1 capsule)

French Maritime Pine Bark Extract (Pinus pinaster), Pycnogenol®: 50mg

Other ingredients: Microcrystalline cellulose, vegetarian capsule, L-leucine, silicon dioxide

Count: 60 capsules

Research

Effect of French maritime pine bark extract on endometriosis as compared with leuprorelin acetate

Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain